Just to remind myself... I found this deep in my old notes...

• Some could be negative, like an infection. You could have the plague, and it'd discourage attacks.
• Some could be positive, and cause you to get attacked more often, to try to steal it.
• They could also move about randomly, reset, or be cast on random players every so often.

If you don't wear a mask while attacking, you catch the plague

It really makes me think of the events that go on right now as a basis. But they could be completely random and infect players, or whatever might be interesting. A meteor hit and released aliens to kill in a temporary map (I wonder if it's possible for you to completely randomise a map layout for things like that?). Or say an infectious alien came to our planet. We're all debuffed until we defeat that global boss enough times, like the global health system we have already on raids/npc. Which would in turn reward players/guilds through their total and personal contribution.

While I agree that’s a fun idea, I feel it might be best to stay away from anything regarding any sort of infection. Might be seen as making light of the current situation and all those that have died from it.